Myristinin A (YM 26567-1) is a trans-isomer flavan compound found in Horsfieldia amygdaline and Myristica cinnamomea . Myristinin A can selectively inhibit COX-2 activity with an IC 50 of 16.9 μg/mL. Myristinin A can reduce the production of prostaglandin E2 (PGE2) and inhibit phospholipase A2 (PLA2), thereby blocking the release of inflammatory mediators. Myristinin A can inhibit Candida albicans with an IC 50 of 8.8 μg/mL. Myristinin A can be used for the research of inflammation and infection , such as rheumatoid arthritis.
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