ORY-1001 dihydrochloride

Overview

ORY-1001 is a lysine specific demethylase 1 inhibitor under the development of Oryzon with IC50 value < 20nM. It selectively inhibits related FAD dependent aminoxidases (MAO-A/B, IL4I1, KDM1B > 100uM, SMOX 7uM). ORY-1001 can induce apoptosis in THP-1 and inhibit proliferation and colony formation of MV(4;11) (MLL-AF4) cells (EC50 <1nM). In THP-1 (MLL-AF9) cells, ORY-1001 results in a time-dose dependent me2H3K4 accumulation at KDM1A target genes and concomitant induction of differentiation markers.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Neurological Disease | LSD1

Product Information

• Catalog No.: B0084-470857
• CAS No.: 1431326-61-2
• Molecular Formula: C15H24Cl2N2
• Molecular Weight: 303.27
• Purity: >98%
• Storage: Store at -20 °C
• Solubility: Soluble in DMSO.

Source

Original product source