Isostrictiniin

Overview

Isostrictiniin (ITN) is a polyphenolic compound isolated from Nymphaea candida . It upregulates the expression of Nrf2 and HO-1 , while downregulating the expression of Keap1 . Isostrictiniin reduces the phosphorylation levels of JNK , ERK1/2 , p38 , IκBα , and NF-κB p65. Isostrictiniin decreases the levels of pro-inflammatory mediators ( IL-1β , IL-6 , TNF-α , PGE2 ). Isostrictiniin alleviates LPS-induced acute lung injury and exerts protective effects against acute alcoholic liver injury. Additionally, isostrictiniin exhibits anti-inflammatory, antioxidant, and anti-fibrotic activities.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Respiratory Inflammation | Products > Disease Areas > Liver Disease | Products > Disease Areas > Acute Lung Injury | Products > Disease Areas > Liver Injury | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > ERK | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > Heme Oxygenase (HO) | Products > Signaling Pathways > JNK

Product Information

• Catalog No.: HY-N17317
• CAS No.: 1801746-41-7
• Molecular Formula: C27H22O18
• Molecular Weight: 634.45
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source