Ligusticum cycloprolactam

Overview

Ligusticum cycloprolactam is a potent, orally active, and CNS-penetrant TLR4/NF-κB inhibitor, exhibiting anti-inflammatory and neuroprotective activity. Ligusticum cycloprolactam reduces FPR1 expression, inhibits NLRP3 inflammasome, TLR4 /NF-κB, hepatic MAPK and TGF-β signaling, and selectively activates hepatic FXR . Ligusticum cycloprolactam attenuates pro-inflammatory mediator production, enhances anti-inflammatory cytokine secretion, regulates renal uric acid transporters, and preserves intestinal microbiota composition . Ligusticum cycloprolactam can be used for the research of ischemic stroke, hyperuricemic nephropathy, neuroinflammation, and metabolic dysfunction-associated fatty liver disease.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Purine Metabolism | Products > Disease Areas > CNS Infection | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Hyperuricemia | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Collagen | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > Cadherin | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > TGF-β Receptor | Products > Signaling Pathways > FXR | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Toll-like Receptor (TLR) | Products > Signaling Pathways > NF-κB

Product Information

• Catalog No.: HY-N17383
• CAS No.: 2283387-37-9
• Molecular Formula: C15H21NO2
• Molecular Weight: 247.33
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source