2-Oxokolavenol

Overview

2-Oxokolavenol is a selective agonist targeting the farnesoid X receptor ( FXR ), with an EC 50 of ~3.7 μM. 2-Oxokolavenol exerts its activity against Acetaminophen ( HY-66005 )-induced hepatocyte damage in an FXR-dependent manner by binding to the FXR ligand-binding pocket, recruiting co-activators, and inducing FXR transcriptional activity. 2-Oxokolavenol can be naturally extracted from Aglaia spectabilis (a plant of the Aglaia genus in the Meliaceae family) and can be used in research related to liver diseases.

Application

Products | Products > Disease Areas > Others | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Others | Products > Signaling Pathways > FXR

Product Information

• Catalog No.: HY-N1749
• CAS No.: 130395-82-3
• Molecular Formula: C20H32O2
• Molecular Weight: 304.47
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source