6-Methoxymellein

Overview

6-Methoxymellein, a phytoalexin, is a NF-κB inhibitor. 6-Methoxymellein reduces nuclear localization and DNA binding activity of NF-κB p65 and p50 subunits. 6-Methoxymellein decreases mRNA transcription and secretion of IL-6 and IL-8 . 6-Methoxymellein reduces the proportion of CD44 + /CD24 − breast cancer cells, decreases expression of c-Myc , Sox-2 and Oct4 , inhibits proliferation and migration of breast cancer cells, and reduces mammosphere growth. 6-Methoxymellein inhibits fungal growth of Trichophyton rubrum and Botrytis cinerea , and inhibits Trichophyton rubrum biofilm formation via hyphal disintegration. 6-Methoxymellein can be used for the research of breast cancer , tinea corporis, and carrot post-harvest storage rot.

Application

Products | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Fungal Infection | Products > Disease Areas > Cancer | Products > Disease Areas > Infection | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Fungal | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-N19791
• CAS No.: 13410-15-6
• Molecular Formula: C11H12O4
• Molecular Weight: 208.21
• Purity: 99.98%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source