Cucurbitacin IIa (Standard)

Overview

Cucurbitacin IIa (Hemslecin A) (Standard) is the analytical standard for Cucurbitacin IIa ( HY-N1988 ). This product is used for research and analytical applications. Cucurbitacin IIa is an orally active, blood-brain barrier-penetrating EGFR inhibitor with an IC 50 of 1.455 nM for human EGFR . Cucurbitacin IIa induces caspase-3 dependent cell apoptosis , downregulates survivin expression, enhances autophagy levels, disrupts the actin cytoskeleton through actin aggregation, blocks the cell cycle at the G2/M phase, and inhibits the EGFR-MAPK signaling pathway to exert anti-inflammatory activity. Cucurbitacin IIa can be used in research on inflammatory-related diseases, depression, and non-small cell lung cancer and other cancers.

Application

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Product Information

• Catalog No.: HY-N1988R
• CAS No.: 58546-34-2
• Molecular Formula: C32H50O8
• Molecular Weight: 562.73
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source