Gypenoside XLIX

Overview

Gypenoside XLIX is a multifunctional bioactive compound that can be isolated from Gynostemma pentaphyllum, with a K a value of 1.58 μM for its binding to SIRT1 . Gypenoside XLIX acts as a PPAR-α agonist. It inhibits the activation of TLR4 -mediated NF-κB signaling pathway by activating the Sirt1/Nrf2 signaling pathway, reduces ROS accumulation, and alleviates hepatic inflammatory injury in mice with sepsis-induced liver disease. Gypenoside XLIX targets SIRT1 to block YAP-NLRP3 activation and improve sepsis-induced cardiomyopathy. Gypenoside XLIX inhibits apoptosis ( Apoptosis ), pyroptosis ( Pyroptosis ), autophagy ( Autophagy ), lipid peroxidation, pro-inflammatory cytokines and anti-inflammatory cytokines. Gypenoside XLIX alleviates sepsis-induced splenic injury by inhibiting inflammation and oxidative stress, and mitigates sepsis-associated encephalopathy by targeting PPAR-α. Gypenoside XLIX prevents acute kidney injury by inhibiting IGFBP7/IGF1R -mediated programmed cell death and inflammation. Gypenoside XLIX inhibits the expression and activity of vascular cell adhesion molecule-1 in cytokine-induced human endothelial cells. Gypenoside XLIX is applicable to research related to acute liver injury, lung injury, cardiomyopathy, acute splenic injury, sepsis-associated encephalopathy, acute kidney injury, atherosclerosis and chronic inflammation.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Chronic Disease and Inflammation | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Respiratory Inflammation | Products > Disease Areas > Heart Disease | Products > Disease Areas > Liver Disease | Products > Disease Areas > Atherosclerosis and Inflammation | Products > Disease Areas > Acute Lung Injury | Products > Disease Areas > Cardiomyopathy | Products > Disease Areas > Liver Injury | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Autophagy | Products > Research Areas > Neurological Disease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > PPAR | Products > Signaling Pathways > Sirtuin | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > Toll-like Receptor (TLR) | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Pyroptosis | Products > Signaling Pathways > Autophagy

Product Information

• Catalog No.: HY-N1990
• CAS No.: 94987-08-3
• Molecular Formula: C52H86O21
• Molecular Weight: 1047.23
• Purity: 99.88%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 6.25 mg/mL (5.97 mM); Clear solution
• Availability: In-stock

Source

Original product source