Higenamine hydrochloride

Overview

Higenamine hydrochloride is a selective LSD1 inhibitor ( IC 50 =1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine (Norcoclaurine) can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine hydrochloride protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine hydrochloride can be used to study cancer , inflammation, cardiorenal syndrome and other diseases .

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Bacterial Infection | Products > Disease Areas > Depression | Products > Disease Areas > Pain | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Cancer | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Infection | Products > Research Areas > Endocrinology | Products > Research Areas > Cardiovascular Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > MAP3K | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > ROS Kinase | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-N2037A
• CAS No.: 11041-94-4
• Molecular Formula: C16H18ClNO3
• Molecular Weight: 307.77
• Purity: 99.34%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture and light)
• Solubility: ≥ 2.08 mg/mL (6.76 mM); Clear solution
• Availability: In-stock

Source

Original product source