Parishin E

Overview

Parishin E is a modulator of hexokinase 2 , lactate dehydrogenase A , and silent information regulator 6 ( sirtuin 6) , and is also a component present in Gastrodia elata Blume. Parishin E reduces the expression of hexokinase 2 and lactate dehydrogenase A , thereby regulating the process of cellular glycolysis. Parishin E regulates the deacetylation mediated by silent information regulator 6 ( Sirtuin 6) , and inhibits histone 3 lactylation modifications at the H3K 18 la and H3K 27 la sites. Parishin E inhibits macrophage polarization. Parishin E alleviates LPS-induced inflammatory responses and suppresses the expression of pro-inflammatory cytokines. Parishin E exerts ameliorating effects on rheumatoid arthritis. Parishin E can be used in studies related to rheumatoid arthritis.

Application

Products | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Arthritis | Products > Disease Areas > Rheumatoid Arthritis | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Hexokinase | Products > Signaling Pathways > Lactate Dehydrogenase | Products > Signaling Pathways > Sirtuin

Product Information

• Catalog No.: HY-N2126
• CAS No.: 952068-57-4
• Molecular Formula: C19H24O13
• Molecular Weight: 460.39
• Purity: 98.90%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 2.5 mg/mL (5.43 mM); Clear solution
• Availability: In-stock

Source

Original product source