Aclacinomycin A (Aclarubicin) is an orally active and potent anthracycline antitumor antibiotic . Aclacinomycin A is an inhibitor of topoisomerase I and II . Aclacinomycin A inhibits synthesis of nucleic acid, especially RNA . Aclacinomycin A might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis.
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