Chelerythrine

Overview

Chelerythrine is a natural alkaloid, acts as a potent and selective Ca 2+ /phospholopid-dependent PKC antagonist, with an IC 50 of 0.7 μM. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC 50 of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Autophagy | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Beta-lactamase | Products > Signaling Pathways > PKC | Products > Signaling Pathways > Bcl-2 Family

Product Information

• Catalog No.: HY-N2359
• CAS No.: 34316-15-9
• Molecular Formula: C21H18NO4
• Molecular Weight: 348.37
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source