9''-Methyl salvianolate B

Overview

9''-Methyl salvianolate B (MSB) is a blood-brain barrier-permeable inhibitor with high affinity for g5Rp , with a K d value of 117 nM against African swine fever virus (ASFV) g5Rp . 9''-Methyl salvianolate B also acts as a ZBP1 inhibitor. It exhibits strong binding affinity to key proteins in the PPARγ / NF-κB pathway. 9''-Methyl salvianolate B blocks the interaction between ASFV g5Rp and host proteins eIF5A or RPS15 . It restores hypusination modification of eIF5A, promotes autophagy ( Autophagy ), and inhibits ASFV replication. 9''-Methyl salvianolate B effectively disrupts ZBP1-mediated PANoptosome assembly. It effectively alleviates myocardial ischemia/reperfusion injury. 9''-Methyl salvianolate B can be used in studies related to African swine fever.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Infection | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Oxidative Stress and Inflammation | Products > Disease Areas > Nervous System Injury | Products > Disease Areas > Viral Infection | Products > Disease Areas > Heart Disease | Products > Disease Areas > Ischemia-Reperfusion Injury | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Autophagy | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > DNA/RNA Synthesis | Products > Signaling Pathways > PPAR | Products > Signaling Pathways > NF-κB

Product Information

• Catalog No.: HY-N2397
• CAS No.: 1167424-31-8
• Molecular Formula: C37H32O16
• Molecular Weight: 732.64
• Purity: 99.54%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 2.5 mg/mL (3.41 mM); Clear solution
• Availability: In-stock

Source

Original product source