Methylophiopogonone A

Overview

Methylophiopogonone A is a homoisoflavonoid compound found in the tuberous roots of Ophiopogon japonicus . Methylophiopogonone A inhibits lipopolysaccharide-induced NO production in mouse microglia with an IC 50 of 19.2 μM. Methylophiopogonone A blocks the proliferation of LX-2 hepatic stellate cells and downregulates TGF-β1-induced expressions of type I collagen and α-SMA . Methylophiopogonone A blocks RELA/EGFR-mediated hepatic stellate cell activation, inhibits the MAPK12 pathway to reduce extracellular matrix accumulation, and simultaneously suppresses inflammatory signal transduction. Methylophiopogonone A can be used in studies related to chronic hepatitis B-associated hepatic fibrosis and neuroinflammation.

Application

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Product Information

• Catalog No.: HY-N2441
• CAS No.: 74805-90-6
• Molecular Formula: C19H16O6
• Molecular Weight: 340.33
• Purity: 99.84%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: 12.5 mg/mL (36.73 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source