Methylnissolin

Overview

Methylnissolin (Astrapterocarpan) is an osteoclast inhibitor with anti-inflammatory, neuroprotective and antioxidant activities. Methylnissolin downregulates the activation of the MAPK and PI3K/AKT pathways, inhibits the phosphorylation of MAPK1 and AKT1 , and blocks PDGF-BB -induced phosphorylation of ERK1/2 . Methylnissolin reduces the expression and secretion of proinflammatory mediators, decreases intracellular ROS levels, upregulates antioxidant enzymes , and downregulates osteoclastogenesis markers. Methylnissolin is applicable to research related to ischemic stroke, osteoporosis, cardiovascular diseases, skin aging, etc.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Oxidative Stress and Inflammation | Products > Disease Areas > Cerebrovascular Disease | Products > Disease Areas > Mineral Metabolism | Products > Disease Areas > Cellular Senescence | Products > Disease Areas > Ischemic Stroke | Products > Disease Areas > Osteoporosis | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Neurological Disease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > PDGFR | Products > Signaling Pathways > ERK

Product Information

• Catalog No.: HY-N2484
• CAS No.: 73340-41-7
• Molecular Formula: C17H16O5
• Molecular Weight: 300.31
• Purity: 99.92%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (8.32 mM); Clear solution
• Availability: In-stock

Source

Original product source