Diphyllin

Overview

Diphyllin is an orally active V-ATPase inhibitor ( IC 50 =17 nM) and HIV-1 inhibitor (IC 50 =0.38 μM). Diphyllin blocks the acidification of osteoclast lysosomes and bone resorption lacunas (IC 50 =0.6 nM for acid influx inhibition)， thereby inhibiting bone resorption. Diphyllin can effectively inhibit osteoclast-mediated bone resorption and has no effect on osteoblastic bone formation. Diphyllin can be used in the research of bone metabolism-related diseases and has the potential to inhibit diseases related to excessive bone resorption.

Application

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Product Information

• Catalog No.: HY-N2532
• CAS No.: 22055-22-7
• Molecular Formula: C21H16O7
• Molecular Weight: 380.35
• Purity: 99.57%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1.43 mg/mL (3.76 mM); Clear solution
• Availability: In-stock

Source

Original product source