Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor ( NNRTI ). Rilpivirine has high antiviral activity against wild-type HIV ( EC 50 =0.4 nM) and mutant viruses ( EC 50 =0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .
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