Kuwanon H (Standard)

Overview

Kuwanon H (Standard) is the analytical standard of Kuwanon H. This product is intended for research and analytical applications. Kuwanon H is a selective non-peptide bombesin receptor antagonist and platelet activation inhibitor. Kuwanon H also acts as a specific antagonist of GRP -preferring receptors, with a K i value of 290 nM for mouse GRP-R and 6500 nM for rat NMB-R . Kuwanon H inhibits the phosphorylation of AKT , mTOR , ERK , cPLA 2 and p38 , and upregulates TRIB3 . It induces endoplasmic reticulum stress, apoptosis and autophagosome formation. Kuwanon H blocks calcium mobilization, mitogenic signaling, DNA synthesis, dense granule secretion, thromboxane A 2 generation and integrin αIIb/β 3 activity. It inhibits collagen-induced platelet aggregation and fibronectin adhesion, and delays clot retraction. Kuwanon H inhibits melanoma cell growth in vitro and in vivo, and enhances the sensitivity of melanoma cells to CDDP. It can be used in research related to melanoma, small cell lung cancer and thrombosis.

Application

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Product Information

• Catalog No.: HY-N2600R
• CAS No.: 76472-87-2
• Molecular Formula: C45H44O11
• Molecular Weight: 760.82
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source