6-Methoxydihydrosanguinarine

Overview

6-Methoxydihydrosanguinarine is an alkaloid with activity across multiple cancer cell types. 6-Methoxydihydrosanguinarine activates IRE1 / JNK signaling, blocks Akt / mTOR and PI3K / AKT / mTOR pathways, reduces expression of Cdc25C, CyclinB1, Cdc2, YAP / TAZ , Survivin , GPX4 , and EGFR , upregulates IRE1 and DR5 , and activates JNK and caspases . 6-Methoxydihydrosanguinarine induces apoptosis , G2/M phase arrest, DNA damage, ROS generation, lipid peroxidation, ferroptosis , autophagy , and suppresses cancer cell growth. 6-Methoxydihydrosanguinarine disruptes the biofilm formation of Candida albicans ( C. albicans ). 6-Methoxydihydrosanguinarine can be used for the research of non-small cell lung cancer , hepatocellular carcinoma, melanoma, colon carcinoma, ovarian cancer and breast cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Infection | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Fungal Infection | Products > Disease Areas > Urogenital Cancer | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Autophagy | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > JNK | Products > Signaling Pathways > IRE1 | Products > Signaling Pathways > Akt | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > YAP | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > Fungal

Product Information

• Catalog No.: HY-N3000
• CAS No.: 72401-54-8
• Molecular Formula: C21H17NO5
• Molecular Weight: 363.36
• Purity: 99.88%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 3.85 mg/mL (10.60 mM); Clear solution
• Availability: In-stock

Source

Original product source