Pellitorine

Overview

Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin ( HY-10448 ), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 ( HMGB1 ) and the expression of RAGE/TLR4 . Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin . Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4 and DHODH . Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 ( AaAQP4 ). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer ) and has inhibitory effects on certain bacteria.

Application

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Product Information

• Catalog No.: HY-N3097
• CAS No.: 18836-52-7
• Molecular Formula: C14H25NO
• Molecular Weight: 223.35
• Purity: 98.30%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: 2.5 mg/mL (11.19 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source