Pellitorine (Standard) is the analytical standard of Pellitorine ( HY-N3097 ). Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin ( HY-10448 ), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 ( HMGB1 ) and the expression of RAGE/TLR4 . Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin . Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4 and DHODH . Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 ( AaAQP4 ). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer ) and has inhibitory effects on certain bacteria.
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