Isopimaric acid

Overview

Isopimaric acid is a coniferous tree defense compound. Isopimaric acid binds to AKT and inhibits mTOR phosphorylation, thereby regulating the AKT / mTOR pathway. Isopimaric acid inhibits oxidative stress, inflammation, microglial migration, apoptosis , autophagic flux , ornithine decarboxylase activity, breast cancer proliferation and metastasis, and fungal spore germination. Isopimaric acid also induces M2 microglial polarization, mitochondrial damage, ROS accumulation, starvation-induced colon cancer cell apoptosis , and breast cancer cell cycle arrest. Isopimaric acid activates potassium channels , regulates sodium channels and calcium channels , reduces myocardial excitability, and improves arrhythmia. Isopimaric acid acts as an oxidative substrate for CYP6BW1/3, down-regulates PINK1/Parkin , and regulates calcium homeostasis, oxidative phosphorylation , EMT, and the Wnt pathway. Isopimaric acid exhibits activity against drug-resistant Staphylococcus aureus , repels feeding, and promotes the growth of rice seedlings. Isopimaric acid is suitable for research related to epilepsy, tumors, drug-resistant bacterial infections, atrial fibrillation, hypertension, hyperlipidemia, pulmonary tuberculosis, etc.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Infection | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Pathogens Infection | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Heart Disease | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Bacterial Infection | Products > Disease Areas > Epilepsy | Products > Disease Areas > Tuberculosis | Products > Disease Areas > Hypertension | Products > Disease Areas > Atrial Fibrillation | Products > Disease Areas > Hypercholesterolemia | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Research Areas > Cardiovascular Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Akt | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Potassium Channel | Products > Signaling Pathways > Sodium Channel | Products > Signaling Pathways > Calcium Channel | Products > Signaling Pathways > PINK1/Parkin | Products > Signaling Pathways > Oxidative Phosphorylation | Products > Signaling Pathways > Wnt | Products > Signaling Pathways > Bacterial

Product Information

• Catalog No.: HY-N3463
• CAS No.: 5835-26-7
• Molecular Formula: C20H30O2
• Molecular Weight: 302.45
• Purity: 99.88%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution
• Availability: In-stock

Source

Original product source