Rubrofusarin gentiobioside

Overview

Rubrofusarin gentiobioside (Rrubrofusarin-6-β-gentiobioside) is an orally active weak inhibitor of PTP1B and MAO-A ( IC 50 >100 μM), and its glycosylation modification results in lower biological activity than its aglycone Rubrofusarin ( HY-130307 ). Rubrofusarin gentiobioside promotes AMPK phosphorylation in an LKB1-independent manner and inhibits the mTOR signaling pathway, thereby downregulating the expressions of PPARγ , C/EBPα , as well as FAS , LPL and aP2 . Rubrofusarin gentiobioside inhibits lipid accumulation, reduces body weight and epididymal white adipose tissue volume, improves fatty liver, and shows no cytotoxicity to hepatocytes. Rubrofusarin gentiobioside is widely used in obesity-related studies.

Application

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Product Information

• Catalog No.: HY-N4177
• CAS No.: 24577-90-0
• Molecular Formula: C27H32O15
• Molecular Weight: 596.53
• Purity: 99.07%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 2.5 mg/mL (4.19 mM); Clear solution
• Availability: In-stock

Source

Original product source