Licoflavone B

Overview

Licoflavone B is an orally active flavonoid, with IC 50 values of 23.78 μM and 31.5 μM against SmATPase and SmADPase of Schistosoma mansoni , respectively. Licoflavone B selectively targets viral RdRp , inhibits viral replication, and reduces the expression levels of viral NP and PB2 . Licoflavone B inhibits c-Myc expression and suppresses cancer cell proliferation. Licoflavone B disrupts the tegument of worms, reduces egg production, and induces the death of adult Schistosoma mansoni . Licoflavone B blocks the activation of the MAPK pathway, maintains colonic barrier integrity, inhibits colonic cell apoptosis , and reshapes the gut microbiota. Licoflavone B can be used in research related to influenza, multiple myeloma, schistosomiasis, and ulcerative colitis.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Infection | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Viral Infection | Products > Disease Areas > Parasitic Infection | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Peptic Ulcer Disease | Products > Disease Areas > Blood Disease | Products > Disease Areas > Multiple Myeloma | Products > Disease Areas > Influenza Virus Infection | Products > Disease Areas > Schistosoma Japonicum Infection | Products > Disease Areas > Ulcerative Colitis | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Parasite | Products > Signaling Pathways > Influenza Virus | Products > Signaling Pathways > ATP Synthase | Products > Signaling Pathways > c-Myc

Product Information

• Catalog No.: HY-N4184
• CAS No.: 91433-17-9
• Molecular Formula: C25H26O4
• Molecular Weight: 390.47
• Purity: 99.86%
• Storage: -20°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution
• Availability: In-stock

Source

Original product source