Yangambin

Overview

Yangambin is a PAF receptor antagonist and UGT1A1 / UGT1A3 inhibitor, with an IC 50 of 29.7 μM and a K i of 17.1 μM against human UGT1A1 , and an IC 50 of 56.5 μM and a K i of 66.8 μM against human UGT1A3 . Yangambin blocks PAF -mediated responses, inhibits LTB 4 -mediated neutrophil infiltration, and suppresses inflammatory events and anaphylactic contraction. Yangambin acts as a central nervous system inhibitor to reduce spontaneous activity, and also exhibits analgesic, anticonvulsant, antileishmanial, vasodilatory and hypotensive effects. Yangambin blocks voltage-gated Ca 2+ channels, reduces the production of NO , TNF-α , IL-6 and PGE2 in cells, increases the production of IL-10 , and exerts a protective effect against cardiovascular injury. Yangambin can be used in research related to allergies, cutaneous leishmaniasis, central nervous system diseases and cardiovascular diseases.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Parasitic Infection | Products > Disease Areas > CNS Infection | Products > Disease Areas > Allergy | Products > Disease Areas > Leishmania Infection | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > UGT | Products > Signaling Pathways > Leukotriene Receptor | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > PGE synthase | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > Calcium Channel | Products > Signaling Pathways > Platelet-activating Factor Receptor (PAFR)

Product Information

• Catalog No.: HY-N4267
• CAS No.: 13060-14-5
• Molecular Formula: C24H30O8
• Molecular Weight: 446.49
• Purity: 98.27%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 1.25 mg/mL (2.80 mM); Clear solution
• Availability: In-stock

Source

Original product source