Mexiprostil (MDL 646) is an orally active gastric protectant, being a synthetic analogue of Prostaglandin E1 ( HY-B0131 ). Mexiprostil exhibits significant inhibition of gastric acid secretion caused by Histamine ( HY-B1204 ) and Bethanechol ( HY-B0406 ) in rats, dogs, and cats. Mexiprostil can also inhibit the increase in gastric acid secretion caused by Pentagastrin ( HY-A0261 ) in cats, while it does not have this effect in dogs and rats. Mexiprostil does not cause pregnancy termination. Mexiprostil can be used for research on gastric ulcers.
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