Praeruptorin E

Overview

Praeruptorin E is an orally active pyranocoumarin compound. Praeruptorin E can be isolated from the dried roots of Peucedanum praeruptorum Dunn . Praeruptorin E reduces the expression of NF-κB . Praeruptorin E upregulates the expression of PXR and CYP3A4 . Praeruptorin E inhibits Th2 cytokines, TNF-α , IL6 , MPO , and blocks the Ca 2+ slow channel. Praeruptorin E promotes pulmonary tissue repair and relaxes porcine coronary artery strips. Praeruptorin E protects mice from lipopolysaccharide- and hydrochloric acid-induced acute lung injury. Praeruptorin E can be used in studies related to asthma and acute lung injury.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Respiratory Inflammation | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Acute Lung Injury | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Pregnane X Receptor (PXR) | Products > Signaling Pathways > Cytochrome P450 | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > Calcium Channel | Products > Signaling Pathways > NF-κB

Product Information

• Catalog No.: HY-N6066
• CAS No.: 78478-28-1
• Molecular Formula: C24H28O7
• Molecular Weight: 428.47
• Purity: 99.18%
• Storage: -20°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (5.83 mM); Clear solution
• Availability: In-stock

Source

Original product source