K-252a

Overview

K-252a, a staurosporine analog, inhibits protein kinase , with IC 50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC , PKA , Ca 2+ /calmodulin-dependent kinase type II, and phosphorylase kinase, respectively. K-252a is a potent inhibitor (IC 50 of 3 nM) of the tyrosine protein kinase ( TRK ) activity of the NGF receptor gp140trk, the product of the trk protooncogene.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Signaling Pathways > PKC | Products > Signaling Pathways > PKA | Products > Signaling Pathways > CaMK | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Trk Receptor

Product Information

• Catalog No.: HY-N6732
• CAS No.: 99533-80-9
• Molecular Formula: C27H21N3O5
• Molecular Weight: 467.47
• Purity: 99.02%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (5.35 mM); Clear solution
• Availability: In-stock

Source

Original product source