Manumycin A

Overview

Manumycin A is a polyketide antibiotic and an inhibitor of thioredoxin reductase 1 ( TrxR-1 ). Manumycin A can inhibit the growth of breast cancer cells and exert its anti-tumor activity through LC3 . Manumycin A can downregulate the release of pro-inflammatory cytokines in human monocytes stimulated by TNF α , and has potential anti-inflammatory activity. Manumycin A can inhibit the Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration resistant prostate cancer cells to suppress exosome biogenesis and secretion.

Application

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Product Information

• Catalog No.: HY-N6796
• CAS No.: 52665-74-4
• Molecular Formula: C31H38N2O7
• Molecular Weight: 550.64
• Purity: 98.30%
• Storage: -20°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 1.25 mg/mL (2.27 mM); Clear solution
• Availability: In-stock

Source

Original product source