Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces , Isaria sinclairi and Mycelia sterilia , is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV , with an IC 50 of 3.5 μg/mL for inhibiting HCV infection .
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