Voacamine

Overview

Voacamine is an indole alkaloid with cannabinoid 1 ( CB1 ) antagonistic activity. Voacamine can inhibit nuclear translocation. Voacamine is effective in enhancing the effect of Doxorubicin ( HY-15142A ) as it interferes with the P-glycoprotein ( P-gp ) function. Voacamine promotes apoptosis-independent autophagic cell death in human osteosarcoma cells. Voacamine activates mitochondrial-associated apoptosis signaling pathway and inhibition of PI3K/Akt/mTOR signaling pathway to suppress breast cancer progression. Voacamine inhibits EGFR to exert oncogenic activity against colorectal cancer .

Application

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Product Information

• Catalog No.: HY-N6932
• CAS No.: 3371-85-5
• Molecular Formula: C43H52N4O5
• Molecular Weight: 704.90
• Purity: 99.64%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (3.55 mM); Clear solution
• Availability: In-stock

Source

Original product source