Tubulysin M

Overview

Tubulysin M is a highly cytotoxic anti-microtubule toxin ( anti-microtubule toxins ) that is synthesized as an ADC cytotoxin ( ADC Cytotoxin ). Tubulysin M can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis . Tubulysin M displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC 50 values in the low nanomolar range. Tubulysin M inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Antibody-Drug Conjugate/ADC Related | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > ADC Payloads | Products > Signaling Pathways > Microtubule/Tubulin

Product Information

• Catalog No.: HY-N7053
• CAS No.: 936691-46-2
• Molecular Formula: C38H57N5O7S
• Molecular Weight: 727.95
• Purity: 98.74%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (3.43 mM); Clear solution
• Availability: In-stock

Source

Original product source