D-Arabinopyranose is a rare aldehyde pentose, and its ring-opened form is D-arabinose ( HY-N0059 ). D-arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC 50 is 7.5 mM). D-arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-arabinose is the ring-opened form of the aldopentose D-?Arabinose ( HY-N7082 ).
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