4-Hydroxyderricin

Overview

4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is an orally active, potent selective MAO-B ( Monoamine oxidase inhibitors) inhibitor with an IC 50 of 3.43 μM. 4-Hydroxyderricin also mildly inhibits dopamine β ( DBH )-hydroxylase activity. 4-Hydroxyderricin has antidepressant activity, anti-allergic, anti-diabetic, anti-oxidant, and antitumor effects. 4-Hydroxyderricin promotes apoptosis and cell cycle arrest through regulating PI3K/AKT/mTOR pathway in hepatocellular cells. 4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation. 4-Hydroxyderricin is promising for research of inflammatory diseases.

Application

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Product Information

• Catalog No.: HY-N7204
• CAS No.: 55912-03-3
• Molecular Formula: C21H22O4
• Molecular Weight: 338.40
• Purity: 99.79%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (7.39 mM); Clear solution
• Availability: In-stock

Source

Original product source