GDP-D-mannose disodium consists of GDP-α-D-mannose ( HY-N7389B ) and GDP-β-D-mannose. GDP-α-D-mannose serves as a donor substrate for mannosyltransferases and acts as a precursor of GDP-β-L-fucose. GDP-α-D-mannose exerts competitive inhibition on GTP (with a K i value of 14.7 μM) and non-competitive inhibition on mannose-1-P (with a K i value of 115 μM). GDP-D-mannose disodium is metabolized to GDP-L-fucose ( HY-134433 ) via GMDS ( Gmd ) and TSTA3 ( WcaG ).
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