Azaleatin

Overview

Azaleatin is an orally active inhibitor of hQC , NS2B-NS3 protease and E. coli β-glucuronidase , with IC 50 values of 1.1 μM, 38.00 μg/mL and 0.57 μM, respectively. Azaleatin inhibits the activities of NF-κB , MyD88 , JAK1 , TLR4 , STAT3 , IL-1β , IL-6 , COX-2 , TNF-α and β-glucuronidase , blocks pro-inflammatory signaling pathways, reduces the levels of ROS , MDA and uric acid, elevates the levels of GPx , GSR , GST , SOD , CAT , HO-1 and GSH , scavenges free radicals and exerts reducing capacity. Azaleatin inhibits the expression of pro- apoptotic proteins Bax , Caspase-9 and Caspase-3 , and upregulates the expression of anti-apoptotic protein Bcl-2 . Azaleatin reduces the levels of cardiac injury markers, restores cardiac histological structure, inhibits Aβ aggregation, dengue protease activity, hepatic stellate cell proliferation and cancer cell growth, and also exhibits antibacterial activity. Azaleatin can be used in studies related to subchronic cardiotoxicity, Alzheimer's disease, dengue fever, hyperuricemia, liver fibrosis, gastric cancer and bacterial infections.

Application

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Product Information

• Catalog No.: HY-N7653
• CAS No.: 529-51-1
• Molecular Formula: C16H12O7
• Molecular Weight: 316.26
• Purity: 98.86%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1.25 mg/mL (3.95 mM); Clear solution
• Availability: In-stock

Source

Original product source