THIQ

Overview

THIQ is the first selective agonist of the melanocortin-4 receptor ( MC4R ) , with high affinity and potency for hMC4R ( IC 50 =1.2 nM, EC 50 =2.1 nM) and rMC4R ( IC 50 =0.6 nM, EC 50 =2.9 nM). THIQ maintains low potency at MC1R , MC3R and MC5R . THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants.

Application

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Product Information

• Catalog No.: HY-10624
• CAS No.: 312637-48-2
• Molecular Formula: C33H41ClN6O2
• Molecular Weight: 589.17
• Purity: 98.48%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (4.24 mM); Clear solution
• Availability: In-stock

Source

Original product source