Chitohexaose hexahydrochloride is a small molecular polysaccharide. Chitohexaose hexahydrochloride inhibits the binding of AgW to TLR4 . Chitohexaose hexahydrochloride upregulates IL-10 , inhibits LPS-induced upregulation of ROS , induces alternative activation of macrophages/monocytes, and suppresses LPS-induced production of TNF-α , IL-1β and IL-6 . Chitohexaose hexahydrochloride reverses the mortality of mice challenged with APAP or LPS. Chitohexaose hexahydrochloride can be used in research related to Acetaminophen ( HY-66005 )-induced hepatotoxicity and endotoxemia.
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