Guluronic acid

Overview

Guluronic acid (G2013) is an orally active oxidative stress regulator and anti-inflammatory agent that exerts pharmacological effects by down-regulating various pro-inflammatory and oxidative stress-related genes (such as TLR4 , NF-κB , iNOS , etc.) and inhibiting the activities of COX-2 , MMPs and VEGF . Low-dose Guluronic acid up-regulates the expression of immunoregulatory genes SHIP1 and SOCS1 , thereby effectively inhibiting cancer-related inflammation, tumor angiogenesis, cell adhesion and metastasis, while reducing the accumulation of immunosuppressive cells. Guluronic acid significantly prolongs the survival time of tumor-bearing hosts within a concentration range without direct cytotoxicity, demonstrating favorable safety. Guluronic acid has involved in the research of multiple sclerosis, ankylosing spondylitis, breast cancer and other inflammatory diseases.

Application

Products | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > CNS Infection | Products > Disease Areas > Arthritis | Products > Disease Areas > Spinal Disease | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Experimental Autoimmune Encephalomyelitis | Products > Disease Areas > Experimental Autoimmune Encephalomyelitis | Products > Disease Areas > Ankylosing Spondylitis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > NF-κB | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > NO Synthase | Products > Signaling Pathways > MMP | Products > Signaling Pathways > COX | Products > Signaling Pathways > VEGFR | Products > Signaling Pathways > Toll-like Receptor (TLR)

Product Information

• Catalog No.: HY-N7700
• CAS No.: 15769-56-9
• Molecular Formula: C6H10O7
• Molecular Weight: 194.14
• Purity: 99.98%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 0.5 mg/mL (2.58 mM); Clear solution
• Availability: In-stock

Source

Original product source