Tyroserleutide hydrochloride

Overview

Tyroserleutide hydrochloride is a tripeptide isolated from the degradation products of porcine spleen with antitumor activity. Tyroserleutide hydrochloride can upregulate the expression of the tumor suppressor gene PTEN and inhibit the activity of AKT and PDK1 . Tyroserleutide hydrochloride inhibits tumor cell proliferation and MDM2 phosphorylation by inhibiting the PI3K/AKT pathway, and also upregulates P21, P27, P53, and induces mitochondrial damage and cell apoptosis .

Application

Products | Products > Peptides | Products > Disease Areas > Cancer | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PTEN | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > PDK-1 | Products > Signaling Pathways > Akt

Product Information

• Catalog No.: HY-106263B
• CAS No.: 852982-42-4
• Molecular Formula: C18H28ClN3O6
• Molecular Weight: 417.88
• Purity: 99.92%
• Storage: Sealed storage, away from moisture and light, under nitrogen. Powder -80°C, 2 years , -20°C, 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
• Solubility: ≥ 2.08 mg/mL (4.98 mM); Clear solution
• Availability: In-stock

Source

Original product source