Myricetin 3'-glucoside is an orally active glycosylated flavonoid. Myricetin 3'-glucoside inhibits the cerebral ischemia-induced elevation of inflammatory cytokine levels, including TNF-α , IL-6 and IL-1β . Myricetin 3'-glucoside reverses the cerebral ischemia-mediated downregulation of Bcl-2 protein levels and reduces the cerebral ischemia-induced upregulation of Bax protein levels. Myricetin 3'-glucoside reduces cerebral infarct volume, increases the number of Nissl bodies, and improves neurological function scores in a rat model of middle cerebral artery occlusion (MCAO). Myricetin 3'-glucoside can be used in cerebral ischemia-related research.
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