Amicoumacin B can be produced by actinomycete, strain 04-5195 T .. Amicoumacin B increases the expression of bone morphogenetic protein 2 ( BMP-2 ). Amicoumacin B has inhibitory effect against C. violaceum (MIC = 250 µg/mL). Amicoumacin B has quorum sensing inhibitory activity, and reduces the expression of the C. violaceum operons vioA, vioB, vioD, and vioE, but increases the expression of vioC.
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