Ilicicolin F is a fungal metabolite that has been found in Fusarium and has diverse biological activities. It inhibits T. vivax alternative oxidase and the E. coli ubiquinol oxidase cytochrome bo ( IC 50 s=0.43 and 0.37 μM, respectively) but not the E. coli ubiquinol oxidase cytochrome bd ( IC 50 =85 μM).2 Ilicicolin F is active against the fungi A. fumigatus and C. albicans (MICs=1.66-3.33 and 6.66-13.33 μg/mL, respectively). It is cytotoxic to HeLa cells with an EC 50 value of 0.003 μg/mL.
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