Neoaureothin

Overview

Neoaureothin is a bacterial metabolite that has been found in Streptomyces. It is an androgen receptor (AR) antagonist that inhibits binding of dihydrotestosterone (DHT) to ARs ( IC 50 =13 μM) and inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells ( IC 50 =1.75 nM). Neoaureothin is cytotoxic to A549, HCT116, and HepG2 cells ( IC 50 s=34.3, 47, and 37.2 μg/mL, respectively). It also has nematocidal activity against the pine wood nematode B. xylophilus (LC50=0.84 μg/mL) and increases survival of P. densiflora trees inoculated with B. xylophilus.

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > Bacterial

Product Information

• Catalog No.: HY-N8504
• CAS No.: 59795-94-7
• Molecular Formula: C28H31NO6
• Molecular Weight: 477.55
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source