Ilicicolin H

Overview

Ilicicolin H is a selective and non-ATP-competitive phosphoglycerate kinase 1 (PGK1) ( IC 50 = 9.02 μM) and mitochondrial cytochrome bc1 reductase ( IC 50 = 2-3 ng/mL) inhibitor. Ilicicolin H directly binds to PGK1 with K D of 60 μM .Ilicicolin H can inhibit cell proliferation and induce apoptosis . Ilicicolin H can inhibit the lactate production and glucose uptake of hepatocellular carcinoma (HCC) cells. Ilicicolin H has a broad antifungal spectrum including C. albicans , Cryptococcus and A. fumigatus . Ilicicolin H can be used for the researches of cancer and infection , such as hepatocellular carcinoma (HCC) and C. albicans infection .

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Infection | Products > Signaling Pathways > Phosphoglycerate Kinase (PGK) | Products > Signaling Pathways > Fungal | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-N8540
• CAS No.: 12689-26-8
• Molecular Formula: C27H31NO4
• Molecular Weight: 433.54
• Purity: 96.7%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source