Hecubine

Overview

Hecubine is a monoterpene indole alkaloid found in Ervatamia ocinalis . Hecubine activates TREM2 expression, reduces LPS ( HY-D1056 )-stimulated inammatory cytokines ( TNF-α 、 IL-6 、 IL-1β ) overexpression, as well as suppresses the levels of TLR4- , MyD88- , MAPK/PI3K/AKT- and NF-κB- related proteins. Hecubin also exhibits antioxidative effect, reduces ROS production and activates of the Nrf2/HO-1 pathway. Hecubine rescues LPS-induced behavioral deficits in zebrash larvae. Hecubine can be used for the research of neural inflammation-associated central nervous system diseases.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > MyD88 | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > Heme Oxygenase (HO) | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > Akt | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > TREM receptor | Products > Signaling Pathways > Toll-like Receptor (TLR)

Product Information

• Catalog No.: HY-N9164
• CAS No.: 62874-52-6
• Molecular Formula: C20H26N2O
• Molecular Weight: 310.43
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source