Emodinanthrone

Overview

Emodin anthrone (EmodAn) is a MARCH7 stabilizer that inhibits ferroptosis ( EC 50 =70 nM). Emodin anthrone is also a precursor to Emodin ( HY-14393 ) and possesses antibiotic activity. Emodin anthrone directly binds to MARCH7 and blocks its ubiquitination-mediated degradation at the K608 site; this action enhances MARCH7-mediated K48 ubiquitination and degradation of NCOA4 , as well as its regulation of the intracellular localization of TFR1 via K63 ubiquitination, thereby reducing the intracellular labile iron pool and blocking ferroptosis . Emodin anthrone demonstrates in vivo cardioprotective effects and exhibits a favorable safety profile. Emodin anthrone is applicable to research on ferroptosis-related cardiovascular diseases, including Doxorubicin ( HY-15142A )-induced cardiomyopathy and myocardial ischemia-reperfusion injury.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Infection | Products > Disease Areas > Heart Disease | Products > Disease Areas > Cardiomyopathy | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > Antibiotic

Product Information

• Catalog No.: HY-N9362
• CAS No.: 491-60-1
• Molecular Formula: C15H12O4
• Molecular Weight: 256.25
• Purity: 98.66%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source