Emodinanthrone (Standard)

Overview

Pro-xylane (Standard) is the analytical standard of Pro-xylane. This product is intended for research and analytical applications. Emodin anthrone (EmodAn) is a MARCH7 stabilizer that inhibits ferroptosis ( EC 50 =70 nM). Emodin anthrone is also a precursor to Emodin ( HY-14393 ) and possesses antibiotic activity. Emodin anthrone directly binds to MARCH7 and blocks its ubiquitination-mediated degradation at the K608 site; this action enhances MARCH7-mediated K48 ubiquitination and degradation of NCOA4 , as well as its regulation of the intracellular localization of TFR1 via K63 ubiquitination, thereby reducing the intracellular labile iron pool and blocking ferroptosis . Emodin anthrone demonstrates in vivo cardioprotective effects and exhibits a favorable safety profile. Emodin anthrone is applicable to research on ferroptosis-related cardiovascular diseases, including Doxorubicin ( HY-15142A )-induced cardiomyopathy and myocardial ischemia-reperfusion injury.

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Others | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Infection | Products > Signaling Pathways > Reference Standards | Products > Signaling Pathways > Antibiotic | Products > Signaling Pathways > Ferroptosis

Product Information

• Catalog No.: HY-N9362R
• CAS No.: 491-60-1
• Molecular Formula: C15H12O4
• Molecular Weight: 256.25
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source