Chaetoglobosin Vb

Overview

Chaetoglobosin Vb is a novel cytotoxic alkaloid with anti-inflammatory and antioxidant activities. Chaetoglobosin Vb can inhibit oxidative stress induced by LPS stimulation, reduce the production of reactive oxygen species and increase the expression of the antioxidant enzyme superoxide dismutase ( SOD ). Chaetoglobosin Vb significantly reduced the gene and protein expression of inducible nitric oxide synthase ( iNOS ) and cyclooxygenase-2 ( COX-2 ) induced by LPS, and alleviated the production of proinflammatory cytokines such as TNF-α, IL-6 and IL-1β. Chaetoglobosin Vb exerts its biological activity through the TLR4-mediated MyD88-dependent signaling pathway and the TRIF-dependent signaling pathway, which is specifically manifested by inhibiting the phosphorylation of p38, ERK , and JNK MAPK and the translocation of NF-κB p65 subunit to the nucleus. Chaetoglobosin Vb showed no cytotoxic effect in the concentration range of 25-100 μM and promoted SOD enzyme activity and phosphorylation of p38, ERK1/2 and JNK in a dose-dependent manner.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Research Areas > Inflammation/Immunology

Product Information

• Catalog No.: HY-N9541
• CAS No.: 1399690-75-5
• Molecular Formula: C32H36N2O5
• Molecular Weight: 528.64
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source