Kp7-6

Overview

Kp7-6 is a Fas mimetic peptide and also a Fas/FasL antagonist. Kp7-6 specifically binds to Fas and FasL , disrupts receptor complexes, and blocks downstream apoptosis signaling pathways. Kp7-6 inhibits the phosphorylation of ERK1-2 , induces the phosphorylation of IκBα , and activates NF-κB . Kp7-6 inhibits the activation of caspase-8 , caspase-3 and JNK , and suppresses human amylin-induced β-cell apoptosis . Kp7-6 inhibits FasL -induced lymphoid cytotoxicity and apoptosis . Kp7-6 reduces local tumor FasL expression, increases CD8 + Fas + T cell infiltration, and decreases tumor volume in pancreatic neuroendocrine tumor models. Kp7-6 prevents concanavalin A-induced liver injury in mice. Kp7-6 is applicable to research related to type 2 diabetes, concanavalin A-induced hepatitis and pancreatic neuroendocrine tumors.

Application

Products | Products > Peptides | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Autoimmune Disease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > JNK | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > PERK | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Caspase

Product Information

• Catalog No.: HY-P10102
• CAS No.: 629628-53-1
• Molecular Formula: C48H56N10O15S2
• Molecular Weight: 1077.15
• Purity: 99.28%
• Storage: Sealed storage, away from moisture. Powder -80°C, 2 years , -20°C, 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (2.32 mM); Clear solution
• Availability: In-stock

Source

Original product source